Vivien Measday, Ph.D.

Associate Professor, Wine Research Centre
Associate Member – Department of Biochemistry and Molecular Biology
Associate Member – Michael Smith Laboratories, Genomics Group
phone: 6048275744
fax: 6048225143
Room 325, 2205 East Mall
Food, Nutrition and Health Building
Vancouver, BC V6T1Z4

Wine Yeast Research

My research focuses on the study of yeast populations associated with the vineyards of British Columbia’s Okanagan Valley. We partner with the BC Wine Grape Council and associated wineries to perform spontaneous fermentations and isolation of the wine yeast Saccharomyces cerevisiae (S. cerevisiae). Using high-throughput genotypic analyses, we generate a genetic fingerprint of each S. cerevisiae strain and compare it to a fingerprint database of S. cerevisiae commercial wine yeast strains that we have generated. Our goal is to identify S. cerevisiae indigenous to the Okanagan Valley with enological potential. We collaborate with Dr. Dan Durall’s laboratory at UBC-Okanagan to achieve this goal.


  • Survey of yeast populations associated with Pinot Noir grapes in 3 Okanagan sub-regions: Oliver-Osoyoos, Penticton-Naramata, Kelowna
  • Comparison of yeast populations in Pinot Gris and Pinot Noir winery versus vineyard fermentations
  • Isolation and characterization of non-Saccharomyces yeast isolated from spontaneous fermentations
  • Characterization of Saccharomyces uvarum associated with Okanagan white wine fermentations – in collaboration with Dr. Dan Durall’s lab
  • Fungal community identification from Pinot Noir and Pinot Gris fermentations using high-throughput Illumina amplicon sequencing

Retrotransposon Research

My lab uses S. cerevisiae as a model system to study retrotransposition. Retrotransposons are repetitive DNA elements in the genome that can replicate and insert a new copy into the genome via an RNA intermediate. We study the Ty1 retrotransposon which has a structure and life cycle similar to human immunodeficiency virus type 1 (HIV-1) except that Ty1 does not exit the cell. Our focus is to identify host factors that interact with integrase, a conserved protein that is required for insertion of retroviral/retrotransposon DNA into the genome.


  • Characterization of the interaction between RNA Polymerase III and Ty1-Integrase
  • The role of the Nuclear Pore Complex in Ty1element genome integration
  1. Martiniuk, J.T., Pacheco, B., Russell, G., Tong, S., Backstrom, I. and Measday, V. (2016) “Impact of Commercial Strain Use on Saccharomyces cerevisiae Population Structure and Dynamics in Pinot Noir Vineyards and Spontaneous Fermentations of a Canadian Winery” PLOS ONE, Aug 23;11(8):e0160259 (IF = 3.7)
  2. Cheung, S., Ma, L., Chan, P.H., Hu, H.L., Mayor, T., Chen, H.T. and Measday, V.  (2016) “Ty1 integrase interacts with RNA Polymerase III-specific subcomplexes to promote insertion of Ty1 elements upstream of Polymerase (Pol) III-transcribed genes” Journal of Biological Chemistry, Mar18; 291(12): 6396-411
  3. Measday, V. and Stirling, P.C.  (2016) “Navigating yeast genome maintenance with functional genomics” Briefings in Functional Genomics, Mar; 15(2): 119-29
  4. Ma L., Ho K., Piggott N., Luo Z., Measday V. (2012) “Interactions between the kinetochore complex and the protein kinase A pathway in Saccharomyces cerevisiae” G3 (Bethesda). Jul 2(7):831-41
  5. Anderson, M. J., Barker, S. L., Boone, C. and Measday, V. (2011) “Identification of RCN1 and RSA3 as ethanol tolerant genes in Saccharomyces cerevisiae using a high copy barcoded library” FEMS Yeast Research Nov 12 (epub ahead of print, IF = 2.5)
  6. Fang, N. N., Ng, A. H. M., Measday, V. and Mayor, T. (2011) “Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turn-over of cytosolic misfolded proteins” Nature Cell Biology Oct 9; 13(11): 1344-52 (IF = 19.6)
  7. Piggott, N., Cook, M., Tyers, M. and Measday, V.  (2011) “Genome-wide fitness profiles reveal a   requirement for autophagy during yeast fermentation”  G3:  Genes, Genomes, Genetics 1: 353-367 (journal cover image from our paper, new journal, no IF yet)
  8. Walkey, C.J., Luo, Z., Borcher, C.H., Measday, V. and van Vuuren, H.J.  (2011) “The Saccharomyces cerevisiae fermentation stress response protein Igd1/Yfr017p regulates glycogen levels by inhibiting the glycogen debranching enzyme” FEMS Yeast Research 11(6): 499-508 (IF = 2.5)
  9. Ma, L., McQueen, J., Cuschieri, L., Vogel, J. and Measday, V.  (2007) “Spc24 and Stu2 promote spindle integrity when DNA replication is stalled” Molecular Biology of the Cell 18(8): 2805-2816 (IF = 6.0)
  10. Baetz, K., Measday, V. and Andrews, B.  (2006) “Revealing Hidden Relationships Among Yeast Genes Involved in Chromosome Segregation Using Systematic Synthetic Lethal and Synthetic Dosage Lethal  Screens” Cell Cycle Vol. 5, Issue 6: 592-595 (IF = 4.5)
  11. Monpetit, B., Thorne, K., Barrett, I., Andrews, K., Jadusingh, R., Hieter, P. and Measday, V.  (2005) “Genome-wide synthetic lethal screens identify an interaction between the nuclear envelope protein, Apq12p, and the kinetochore in Saccharomyces cerevisiae” Genetics 171: 1-13.  (IF = 4.3)
  12. Measday, V#., Baetz, K#., Guzzo, J., Yuen, K., Kwok, T., Sheikh, B., Ding, H., Ueta, R., Hoac, T., Cheng, B., Pot, I., Tong, A., Yamaguchi-Iwai, Y., Boone, C. Hieter, P. and Andrews, B.  (2005)  “Systematic yeast synthetic lethal and synthetic dosage lethality screens identify genes required for chromosome segregation” Proceedings of the National Academy of Sciences USA 102(39): 13956-13961. #authors contributed equally (IF = 10.6)
  13. Measday, V. and Hieter, P.  (2004)  “Kinetochore substructure comes to MIND” Nature Cell Biology 6(2): 94-95. (IF = 19.6)
  14. Pot, I., Measday, V., Snydsman, B., Cagney, G., Fields, S., Davis, T.N., Muller, E.G.D. and Hieter, P. (2003) “Chl4p and Iml3p are two new members of the budding yeast outer kinetochore” Molecular Biology of the Cell 14(2): 460-476. (IF = 6.0)
  15. Measday, V., Hailey, D.W., Pot, I., Givan, S., Hyland, K.M. Cagney, G., Fields, S., Davis, T.N. and Hieter, P. (2002) “Ctf3p, the Mis6 budding yeast homologue, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore” Genes & Development 16(1): 101-113.  (IF = 13.9)
  16. Measday, V. and Hieter, P.  (2002)  “Synthetic Dosage Lethality” Guide to Yeast Genetics and Molecular and Cell Biology, Parts B and C.  Methods in Enzymology 350: 316-326. (IF = 2.2)
  17. McBride, H.J., Sil, A., Measday, V., Yu, Y., Moffat, J., Maxon, M.E., Herskowitz, I., Andrews, B. and Stillman, D.  (2001) “The protein kinase Pho85 is required for asymmetric accumulation of the Ash1 protein in Saccharomyces cerevisiae” Molecular Microbiology 42(2): 345-353. (IF = 5.2)
  18. Macpherson, N., Measday, V., Moore L. and Andrews, B.  (2000) “A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription”  Genetics 154(4): 1561-1576. (IF=4.3)
  19. Measday, V., McBride, H., Moffat J., Stillman D. and Andrews, B. (2000)  “Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast” Molecular Microbiology 35(4): 825-834.  (IF = 5.2)
  20. Andrews, B. and Measday, V. (1998) “The cyclin family of budding yeast:  abundant use of a good idea.  Trends in Genetics” 14(2): 66-72.  (IF = 9.3)
  21. Measday, V., Moore, L., Retnakaran, R., Lee, J., Donoviel, M., Neiman A. M. and Andrews, B. (1997)  “A Family of Cyclin-Like Proteins that Interact with the Pho85 Cyclin-Dependent Kinase” Molecular and Cellular Biology  17(3): 1212-1223. (IF = 6.4)
  22. Ellis, C., Measday, V. and Moran, M.F.  (1995) “Phosphorylation-dependent complexes of p120 Ras-specific GTPase-activating protein with p62 and p190” Methods in Enzymology 255: 179-192. (IF = 2.2)
  23. Measday, V., Moore, L., Ogas, J., Tyers, M. and Andrews, B. (1994) “The Pcl2 (OrfD)-Pho85 Cyclin-Dependent Kinase Complex, a Cell Cycle Regulator in Yeast” Science 266: 1391-1395.  (IF = 31.8)


University of British Columbia, 2003, Post-doctoral Research, Dept. Medical Genetics
University of Toronto, 1998, PhD, Dept. Medical Genetics and Microbiology
University of British Columbia, 1991, BSc, Dept. Biochemistry

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